Sito della Scuola di Anatomia Patologica

dell'Università degli Studi di Milano-Bicocca

  • Dr. Vincenzo L'Imperio

Murine model of PLA2R-associated MN: the last brick in the 10 years wall

Background

Recent animal studies demonstrated a pathogenic role of anti-THSD7A antibodies in the development of MN. The lack of endogenous PLA2R1 expression in rodents precluded analogous antibody transfer studies.


Take home messages:

- Transgenic mPLA2R-expressing mice demonstrated intact nephrin distribution with normal podocyte function

- Transfer of rabbit anti-mPLA2R antibodies to these mice induced nephrotic range proteinuria, hypercholesterolemia, and histomorphological signs of membranous nephropathy

- IHC/IF analyses revealed enhanced staining for mPLA2R in the presence of unaffected staining for mTHSD7A in the diseased mice

- These mice model are crucial to confirm the pathogenecity of anti-PLA2R autoantibodies and will help to better understand the pathomechanism of this disease, that can exploit new therapeutic approaches


https://www.kidney-international.org/article/S0085-2538(19)31115-9/fulltext

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